Nanoengineering of living cells, including probiotics, bacteriophages, and immune cells, has emerged as a simpler, more flexible, and more predictable strategy to enhance the theranostic potential and translational applicability of living medicines. At the NanoProBio Lab, we harness biomimetic nanocatalysts to emulate natural defence and attack systems or to construct robust nanoprobes, enabling innovative approaches for engineering living cells. These strategies empower cells to overcome physiological barriers associated with various administration routes, improve their accumulation and functionality within pathological microenvironments, and ultimately achieve effective therapeutic outcomes and precise disease diagnosis.

Based at the interdisciplinary platform for medicine and engineering of Beihang University, working at the interface of chemistry, nanomaterials, microbiology, cell engineering, and translational science. We have three primary research foci: (1) developing reactive nanocatalysts that mimic natural defence and attack systems to enhance therapeutic efficacy; (2) designing smart probes for highly sensitive disease diagnosis; and (3) employing these nanomaterials to regulate and monitor the functions of living medicines for improved diagnosis and therapy.