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Publications

Selected recent highlights

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Publications

2025

 

  1. Yaling Liu,  Shuwen Sun, Chunyao Shang, Rongji Liu, Chenhao Zhang, Jing Yu, Kai Dong,*  Chen Xu* and Fangfang Cao*. MOF-derived nanozyme loaded with botanicals as multifunctional nano antibiotics for synergistic treatment of intracellular antibiotic-resistant bacterial infection. Nanoscale Horiz. 2025. (Accepted, Invited) 

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2024

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  1. Yongfang Zheng†,*, Xinyu Zhang†, Mingyi Jiang, Fangfang Cao†,*, Qing You†,*, Xiaoyuan Chen*. Development and Applications of D-Amino Acid Derivatives-based Metabolic Labeling of Bacterial Peptidoglycan. Angew. Chem. Int. Ed. 2024, 63, e202319400. 

  2. ​Yining Chen†, Tianshu Zou†, Gaoying Xin, Xin Liu, Yunan Yang, Liqi Wei, Biao Zhang, Pengcheng Yu, Yiping Ren, Yanlin Feng, Rui Chen*, Fangfang Cao*, Xiaoyuan Chen*, Yan Cheng*. Oxygen-independent synchronized ROS generation and hypoxia prodrug activation with Z-scheme heterostructure sonosensitizer. Adv. Mater. 2024, 36, 2307929.

  3. Meiqi Cheng, Xinyang Yu, Shaolong Qi, Kai Yang, Meixin Lu, Fangfang Cao*, Guocan Yu*. Development of organ targeting lipid nanoparticles with low immunogenicity and its application in the treatment of pulmonary fibrosis. Angew. Chem. Int. Ed. 2024, 63, e202407398.

  4. Yanlin Feng†, Jianlin Wang†, Jimin Cao*, Fangfang Cao*, Xiaoyuan Chen*, Manipulating calcium homeostasis with nanoplatforms for enhanced cancer therapy. Exploration, 2024, 4, 20230019. (Invited)

  5. Yongcan Li, Fangfang Cao, Lie Ma, Lulu Jin*, Bacteria-Based Bioactive Materials for Tumor Immunotherapy. Precision Medicine and Engineering, 2024,1, 100013.

  6. Jianhua Zou, Zheng Li, Yang Zhu, Yucen Tao, Qing You, Fangfang Cao, Qinghe Wu, Min Wu*, Junjie Cheng*, Jianwei Zhu*, Xiaoyuan Chen*. pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy. Bioact. Mater. 2024, 34, 414.

  7. Fangfang Cao†, Lulu Jin†, Chenyin Zhang, Yong Gao, Zhefeng Qian, Hongyang Wen, Sisi Yang, Ziqiang Ye, Liangjie Hong, Huang Yang, Zongrui Tong, Liang Cheng, Yuan Ding, Weilin Wang, Guocan Yu*, Zhengwei Mao*, Xiaoyuan Chen*. Engineering clinically relevant probiotics with switchable “nano-promoter” and “nano-effector” for precise tumor therapy. Adv. Mater. 2024, 36, 2304257.

  8. Qing You, Fuming Liang, Gege Wu, Fangfang Cao, Jingyi Liu, Zhaohui He, Chen Wang, Ling Zhu*, Xiaoyuan Chen*, Yanlian Yang*. The Landscape of Biomimetic Nanovesicles in Brain Diseases. Adv. Mater. 2024, 36, 2306583.

  9. Fangfang Cao. In vitro nanomaterial testing: unveiling biases through biomolecular corona influence. Nanoscale Horiz. 2024, 9, 1070. (Editorial, Invited)

  10. Kai Dong, Wenbo Lin, Tianyu Zhu, Shuwen Sun, Chenhao Zhang, Chen Xu*, Fangfang Cao*, Xiaoyuan Chen*. NIR-actuated botanicals/nanozymes nanofibrous membranes for antibiotic-free triple-synergistic therapy against polymicrobial wound infections. Adv. Healthcare Mater. 2024, 2401657. (Invited)

 

 

2023

 

  1. Fangfang Cao, Lulu Jin, Yong Gao, Yuan Ding, Hongyang Wen, Zhefeng Qian, Chenyin Zhang, Liangjie Hong, Huang Yang, Jiaojiao Zhang, Zongrui Tong, Weilin Wang*, Xiaoyuan Chen*, Zhengwei Mao*. Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis. Nat. Nanotechnol. 2023, 18, 617. (Hot paper)

  2. Chunxiong Zheng†, Qingguo Zhong†, Ke Yi, Huimin Kong, Fangfang Cao*, Chenya Zhuo, Yanteng Xu, Run Shi, Enguo Ju, Wantong Song, Yu Tao*, Xiaoyuan Chen*, Mingqiang Li*. Anti-phagocytosis-blocking repolarization-resistant membrane-fusogenic liposome (ARMFUL) for adoptive cell immunotherapy. Sci. Adv. 2023, 9, eadh2413.

  3. Xinyang Yu†, Shaolong Qi†, Fangfang Cao†, Kai Yang, Hongjian Li, Kun Peng, Zhida Liu*, Bing Bai, Marija Buljan*, Xiaoyuan Chen*, Guocan Yu*. Fabrication of an immunostimulatory supramolecular nanomedicine for potent cancer chemoimmunotherapy. J. Am. Chem. Soc., 2023, 3, 3181.

  4. Yong Gao, Fangfang Cao, Zhengwei Mao*, Xiaoyuan Chen*. Nanozymes for Prooxidative Therapy. Biomedical Nanozymes: From Diagnostics to Therapeutics. Springer Nature, Singapore. 2023,165. (Editorial, Invited)

  5. Lulu Jin, Fangfang Cao, Yong Gao, Chenyin Zhang, Zhefeng Qian, Jiaojiao Zhang, Zhengwei Mao*. Microenvironment-activated nanozyme-armed bacteriophages efficiently combat bacterial infection. Adv. Mater. 2023, 35, 2301349.

  6. Yanlin Feng†, Xin Ning†, Jianlin Wang, Zhaoyang Wen, Fangfang Cao*, Qing You, Jianhua Zou, Xin Zhou, Teng Sun, Jimin Cao*, Xiaoyuan Chen*. Mace-like plasmonic Au-Pd heterostructures boost near-infrared photoimmunotherapy. Adv. Sci. 2023,10, 2204842.

  7. Yanlin Feng†, Jianlin Wang†, Xin Ning, Aiyun Li, Qing You, Wanzhen Su, Deping Wang, Jianyun Shi, Lan Zhou, Fangfang Cao*, Xiaoyuan Chen*, Jimin Cao*. BaTiO3@Au nanoheterostructure suppresses triple-negative breast cancer by persistently disrupting mitochondrial energy metabolism. Nano. Res. 2023, 16, 2775.

 

2022

  1. Fangfang Cao, Yanjuan Sang, Chaoying Liu*, Fuquan Bai, Lirong Zheng, Jinsong Ren*, Xiaogang Qu*. Self-adaptive single-atom catalyst boosting selective ferroptosis in tumor cells. ACS Nano, 2022, 16, 855. (Highly cited paper)

 

2021

 

  1. Yanjuan Sang, Qingqing Deng, Fangfang Cao, Zhengwei Liu, Yawen You, Hao Liu, Jinsong Ren*, Xiaogang Qu*. Remodeling macrophages by an iron nanotrap for tumor growth suppression. ACS Nano, 2021, 15, 19298.

  2. Lingjun Tong, Haining Hao, Zhe Zhang, Youyou Lv, Xi Liang, Qiqi Liu, Tongjie Liu, Pimin Gong, Lanwei Zhang, Fangfang Cao, Giorgia Pastorin, Chuen Neng Lee, Xiaoyuan Chen, Jiong-Wei Wang, Huaxi Yi. Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota. Theranostics, 2021, 11, 8570.

 

2020

  1. Fangfang Cao, Lu Zhang, Yawen You, Lirong Zheng, Jinsong Ren*, Xiaogang Qu*. An enzyme-mimicking single-atom catalyst as an efficient multiple reactive oxygen and nitrogen species scavenger for sepsis management. Angew. Chem. Int. Ed. 2020, 59, 5108. (Highly cited paper)

  2. Yawen You, Fangfang Cao, Yajie Zhao, Qingqing Deng, Yanjuan Sang, Yang Li, Kai Dong, Jinsong Ren*, Xiaogang Qu*. Near-Infrared Light Dual-Promoted Heterogeneous Copper Nanocatalyst for Highly Efficient Bioorthogonal Chemistry in Vivo. ACS Nano, 2020, 14, 4178.

  3. Yanjuan Sang, Fangfang Cao, Wei Li, Lu Zhang, Yawen You, Qingqing Deng, Kai Dong, Jinsong Ren*, Xiaogang Qu*. Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy. J. Am. Chem. Soc. 2020, 142, 5177.

 

2019

  1. Yan Zhang, Lu Zhang, Zhenzhen Wang, Faming Wang, Lihua Kang*, Fangfang Cao, Kai Dong, Jinsong Ren*, Xiaogang Qu*. Renal-clearable ultrasmall covalent organic framework nanodots as photodynamic agents for effective cancer therapy. Biomaterials, 2019, 223, 119462.

  2. Fangfang Cao, Lu Zhang, Huan Wang, Yawen You, Ying Wang*, Nan Gao, Jinsong Ren*, Xiaogang Qu*. Defect-rich adhesive nanozymes as efficient “antibiotics” for enhanced bacterial inhibition. Angew. Chem. Int. Ed. 2019, 58, 16236. (Highly cited paper)

  3. Lu Zhang, Yan Zhang, Zhenzhen Wang, Fangfang Cao, Yanjuan Sang, Kai Dong, Fang Pu, Jinsong Ren, Xiaogang Qu. Constructing metal–organic framework nanodots as bio-inspired artificial superoxide dismutase for alleviating endotoxemia. Mater. Horiz., 2019, 6, 1682.

 

2018

  1. Fangfang Cao, Yan Zhang, Yuhuan Sun, Zhenzhen Wang, Lu Zhang, Yanyan Huang, Chaoqun Liu, Zhen Liu, Jinsong Ren*, Xiaogang Qu*. Ultrasmall nanozymes isolated within porous carbonaceous frameworks for synergistic cancer therapy: enhanced oxidative damage and reduced energy supply. Chem. Mater. 2018, 30, 7831.

  2. Lu Zhang, Zhenzhen Wang, Yan Zhang, Fangfang Cao, Kai Dong, Jinsong Ren*, Xiaogang Qu*. Erythrocyte membrane cloaked metal–organic framework nanoparticle as biomimetic nanoreactor for starvation-activated colon cancer therapy. ACS Nano, 2018, 12, 10201.

  3. Zhenzhen Wang, Yan Zhang, Enguo Ju, Zhen Liu, Fangfang Cao, Zhaowei Chen, Jinsong Ren*, Xiaogang Qu*. Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors. Nat. Commun., 2018, 9, 3334.

  4.  Zhaowei Chen, Chaoqun Liu, Fangfang Cao, Jinsong Ren*, Xiaogang Qu*. DNA metallization: principles, methods, structures, and applications. Chem. Soc. Rev., 2018, 47, 4017.

 

2017

  1. Enguo Ju†, Kai Dong†, Zhenzhen Wang, Yan Zhang, Fangfang Cao, Zhaowei Chen, Fang Pu, Jinsong Ren*, Xiaogang Qu*. Confinement of reactive oxygen species in an artificial-enzyme-based hollow structure to eliminate adverse effects of photocatalysis on UV filters. Chem. Eur. J., 2017, 23, 13518.

  2. Chaoqun Liu, Yan Zhang, Min Liu, Zhaowei Chen, Youhui Lin, Wei Li, Fangfang Cao, Zhen Liu, Jinsong Ren, Xiaogang Qu. A NIR-controlled cage mimicking system for hydrophobic drug mediated cancer therapy. Biomaterials, 2017, 139, 151.

  3. Fangfang Cao, Enguo Ju, Yan Zhang, Zhenzhen Wang, Chaoqun Liu, Wei Li, Yanyan Huang, Kai Dong, Jinsong Ren*, and Xiaogang Qu*. An efficient and benign antimicrobial depot based on silver-infused MoS2. ACS Nano, 2017, 11, 4651.

  4. Fangfang Cao, Enguo Ju, Chaoqun Liu, Wei Li, Yan Zhang, Kai Dong, Zhen Liu, Jinsong Ren*, Xiaogang Qu*. Encapsulation of aggregated gold nanoclusters in a metal-organic framework for real-time monitoring of drug release. Nanoscale, 2017, 9, 4128.

 

2016

  1. Fangfang Cao, Enguo Ju, Chaoqun Liu, Fang Pu*, Jinsong Ren*, Xiaogang Qu*. Coupling a DNA-ligand ensemble with Ag cluster formation for the label-free and ratiometric detection of intracellular biothiols. Chem. Commun. 2016, 52, 5167.

Beihang University, Beijing

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