Research Interests 

• Cell and microbial therapy for translational medicine

Focus on the engineering of therapeutic cells and microbes—including probiotics and immune cells—for the treatment of inflammatory diseases, cancer, and metabolic disorders. Emphasis is placed on optimizing their therapeutic efficacy through genetic and nanomaterial-based modifications, microenvironment-responsive regulation, and targeted delivery systems, with the goal of bridging the gap between basic research and clinical application.

 

• Nanocatalytic medicine

Development of nanozyme-based and catalyst-activated therapeutic platforms, including artificial enzymes, bioorthogonal catalysts, plasma-driven systems, and piezoelectric nanomaterials. These platforms are engineered to modulate redox balance and cellular metabolism, catalyze in situ chemical transformations within living systems, and selectively activate prodrugs at disease sites. Their applications span cancer therapy, inflammation regulation, and antimicrobial intervention.

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• Nanoprobes for bioimaging and biosensors

Design and synthesis of intelligent nanoprobes for high-resolution imaging and real-time biosensing. Research focuses on fluorescence, photoacoustic, chemiluminescent, and magnetic signal-responsive probes capable of detecting specific biomolecules, reactive species, or cellular events in complex biological environments. These advanced tools are essential for early disease diagnosis, therapeutic monitoring, and mechanistic studies of pathophysiological processes.

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• Flexible electronic devices for biomedical applications

Exploration of stretchable and biocompatible electronic materials for seamless integration with biological tissues. Research focuses on the development of wearable sensors for continuous physiological monitoring, implantable devices for spatiotemporally controlled drug delivery, and flexible electronic patches for the repair of gastrointestinal fistulas and other soft tissue defects. Emphasis is placed on materials and system-level design enabling conformal contact, mechanical resilience, and long-term stability in vivo.